Gang Li Lab 
Chemoproteomics

PUBLICATIONS
2024

18. Protein-templated ligand discovery via the selection of DNA-encoded dynamic libraries

Yu Zhou, Wenyin Shen, Ying Gao, Jianzhao Peng, Qingrong Li, Xueying Wei, Shihao Liu, Fong Sang Lam, Joan Mayol-Llinàs, Guixian Zhao, Gang Li, Yizhou Li, Hongzhe Sun*, Yan Cao*& Xiaoyu Li*, Nature Chemistry, 2024.

17. Global profiling of functional histidines in live cells using small molecule photosensitizer and chemical probe relay labeling

Yansheng Zhai, Xinyu Zhang, Zijing Chen, Dingyuan Yan, Lin Zhu, Zhe Zhang, Xianghe Wang, Kailu Tian, Yan Huang, Xi Yang, Wen Sun, Dong Wang, Yu-Hsuan Tsai , Tuoping Luo, & Gang Li*, Nature Chemistry2024, Accepted. (Research Square: https://doi.org/10.21203/rs.3.rs-2981935/v1)


2023

16. Machine-Learning-Based Data Analysis Method for Cell-Based Selection of DNA-Encoded Libraries

Rui Hou*, Chao Xie, Yuhan Gui, Gang Li, Xiaoyu Li*, ACS Omega, 2023, 8, 19057–19071.


2022

15. Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling

Yansheng Zhai#, Xiaoyan Huang#, Keren Zhang, Yuchen Huang, Yanlong Jiang, Jingwei Cui, Zhe Zhang, Cookson Chiu, Weiye Zhong, Gang Li. Nature Communications, 2022, 13, 4906. 【Editors' Highlights】

14. Converting Double-Stranded DNA-Encoded Libraries (DELs) to Single-Stranded Libraries for More Versatile Selections

Yuhan Gui, Clara Shania Wong, Guixian Zhao, Chao Xie, Rui Hou, Yizhou Li*, Gang Li*, and Xiaoyu Li*, ACS Omega, 2022, 7, 13, 11491–11500


2020

13. In vivo imaging of the tumor-associated enzyme NCEH1 with a covalent PET probe

Raymond E. Moellering* Jae Won Chang, Mohammed Bhuiyan, Hsiu-Ming Tsai, Hannah J. Zhang, Gang Li, Shaghayegh Fathi, David C. McCutcheon, Lara Leoni, Richard Freifelder, Chin-Tu Chen, Angew. Chem. Int. Ed., 2020, 59(35), 15161-15165.



2019

12. Ultrasensitive, multiplexed chemoproteomic profiling with soluble activity-dependent proximity ligation

Gang Li, Mark A. Eckert, Jae W. Chang, Jeffrey E. Montgomery, Agnieszka Chryplewicz, Ernest Lengyel, Raymond E. Moellering*, Proc. Natl. Acad. Sci. U.S.A. 2019, 116, 21493-21500.

11. A concise, modular antibody-oligonucleotide conjugation strategy based on disuccinimidyl ester activation chemistry

Gang Li, Raymond E. Moellering*, ChemBioChem, 2019, 20, 1599-1605.

10. Chemical probes for spatially resolved measurement of active enzymes in single cells 

Gang Li, Raymond E. Moellering*, Methods Enzymol. 2019, 628, 243-262.

9. Proteomics reveals NNMT as a master metabolic regulator of cancer associated fibroblasts

Mark A. Eckert, Fabian Coscia, Agnieszka Chryplewicz, Jae W. Chang, Kyle M. Hernandez, Shawn Pan, Samantha M. Tienda, Dominik A. Nahotko, Gang Li, Ivana Blaženović, Ricardo R. Lastra, Marion Curtis, S. Diane Yamada, Ruth Perets, Stephanie M. McGregor, Jorge Andrade, Oliver Fiehn, Raymond E. Moellering, Matthias Mann, Ernst Lengyel*, Nature, 2019, 569, 723-728

2017

8. An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells

Gang Li, Jeffrey E. Montgomery, Mark A. Eckert, Jae W. Chang, Sam M. Tienda, Ernest Lengyel, Raymond E. Moellering*, Nat. Commun.2017, 8, 1775-1787.
7. Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

Shreya Mitra, Jeffrey E. Montgomery, Matthew J. Kolar, Gang Li, Kang J. Jeong, Bo Peng, Gregory L. Verdine, Gordon B. Mills, Raymond E. Moellering*Nat. Commun.2017, 8, 660-670.

2016
6. Enantioselective synthesis of Iboga alkaloids and vinblastine via rearrangements of quaternary ammoniums

Yun Zhang, Yibin Xue, Gang Li, Haosen Yuan, Tuoping Luo*, Chem. Sci. 2016, 7, 5530-5536.

2015

5. Design, preparation, and selection of DNA-encoded dynamic libraries

Gang Li, Wenlu Zheng, Zitian Chen, Yu Zhou, Yu Liu, Junrui Yang, Yanyi Huang, Xiaoyu Li*, Chem. Sci. 2015, 6, 7097-7104. 
4. Novel encoding methods for DNA-templated chemical libraries

Gang Li, Wenlu Zheng, Ying Liu, Xiaoyu Li*, Curr. Opin. Chem. Biol. 2015, 26, 25-33. 
3. Affinity purification in target identification: the specificity challenge

Wenlu Zheng, Gang Li, Xiaoyu Li*, Arch. Pharm. Res. 2015, 38, 1661-1685. 

2014

2. Multivalent photoaffinity probe for labeling small molecule binding proteins

Gang Li, Yu Liu, Xuerong Yu, Xiaoyu Li*, Bioconjugate Chem. 2014, 25, 1172-1180.


2013

1. Photoaffinity labeling of small-molecule-binding proteins by DNA-templated chemistry

Gang Li, Ying Liu, Yu Liu, Li Chen, Siyu Wu, Yang Liu, Xiaoyu Li*, Angew. Chem. Int. Ed. 2013, 52, 9544-9549.