The research at chemical proteomics group lies at the interface of chemical biology and system biology, which enable us to launch basic research as well as translational applications. Our research directions are as follows:

• (1) Protein–protein interaction mapping
  We develop proximity labeling and crosslinking mass spectrometry platforms to study protein–protein interactions. These tools help identify substrates of ubiquitin ligases and deubiquitinases, uncovering new ubiquitination-related targets for cancer therapy.                                                                                                                                                                                                                

• (2) Functional amino acid profiling
  We establish proteome-wide methods to study functional amino acids such as histidine and arginine. This enables covalent ligand discovery for undruggable proteins, inhibitors of protein–protein interactions, and functional studies of RNA-binding proteins.

• (3) Library-versus-proteome screening
  We build small-molecule library–proteome screening platforms for ultra–high-throughput discovery of enzyme inhibitors and covalent ligands. The identified molecules serve as chemical probes for studying protein function and as candidate compounds for therapeutic development, including applications in prostate cancer and cancer immunoregulation.