22. Discovering Cell-Targeting Ligands and Cell Surface Receptorsby Selection of DNA-Encoded Chemical Libraries against CancerCells without Predefined Targets, Yuhan Gui, Rui Hou, Yuchen Huang, Yu Zhou, Shihao Liu, Ling Meng, Ying Li, Fong Sang Lam, Ruoyun Ding, Yan Cao, Gang Li,* Xiaojie Lu,* and Xiaoyu Li*, Angew. Chem. Int. Ed.,  2025, DOI: 10.1002/anie.202421172.

21. Single-cell chemoproteomics identifies metastatic activity signatures in breast cancer, Kavy Pillai , Olivia Laxton , Gang Li , Jing Lin , Olga Karginova, Rita Nanda , Olufunmilayo I. Olopade , Savaş Tay, and Raymond E. Moellering, Science Advance,  2024, DOI: 10.1126/sciadv.adp2622.

20. Agonist Discovery for Membrane Proteins on Live Cells byUsing DNA-encoded Libraries

Yiran Huang, Rui Hou, Fong Sang Lam, Yunxuan Jia, Yu Zhou, Xun He, Gang Li, Feng Xiong*, Yan Cao*, Dongyao Wang*and Xiaoyu Li*. Journal of the American Chemical Society.  2024.

19.  A key to unlock ubiquitin ligase function.

Shaoshuai Xie, Gang Li*, Nature Chemical Biology. 2024.

18. Protein-templated ligand discovery via the selection of DNA-encoded dynamic libraries

Yu Zhou#, Wenyin Shen#, Ying Gao, Jianzhao Peng, Qingrong Li, Xueying Wei, Shihao Liu, Fong Sang Lam, Joan Mayol-Llinàs, Guixian Zhao, Gang Li, Yizhou Li, Hongzhe Sun*, Yan Cao*& Xiaoyu Li*, Nature Chemistry, 2024.16: 543-555.

17. Global profiling of functional histidines in live cells using small molecule photosensitizer and chemical probe relay labeling

Yansheng Zhai, Xinyu Zhang, Zijing Chen, Dingyuan Yan, Lin Zhu, Zhe Zhang, Xianghe Wang, Kailu Tian, Yan Huang, Xi Yang, Wen Sun, Dong Wang, Yu-Hsuan Tsai , Tuoping Luo, & Gang Li^*, Nature Chemistry, 2024, 

16. Machine-Learning-Based Data Analysis Method for Cell-Based Selection of DNA-Encoded Libraries

Rui Hou*, Chao Xie, Yuhan Gui, Gang Li, Xiaoyu Li*, ACS Omega, 2023, 8, 21, 19057–19071.

15. Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling

Yansheng Zhai^#, Xiaoyan Huang^#, Keren Zhang, Yuchen Huang, Yanlong Jiang, Jingwei Cui, Zhe Zhang, Cookson Chiu, Weiye Zhong, Gang Li^* . Nature Communications, 2022, 13, 4906. 【Editors' Highlights】

14. Converting Double-Stranded DNA-Encoded Libraries (DELs) to Single-Stranded Libraries for More Versatile Selections

Yuhan Gui, Clara Shania Wong, Guixian Zhao, Chao Xie, Rui Hou, Yizhou Li*, Gang Li*, and Xiaoyu Li*, ACS Omega, 2022, 7, 13, 11491–11500

12. Ultrasensitive, multiplexed chemoproteomic profiling with soluble activity-dependent proximity ligation

Gang Li, Mark A. Eckert, Jae W. Chang, Jeffrey E. Montgomery, Agnieszka Chryplewicz, Ernest Lengyel, Raymond E. Moellering*, Proceedings of the National Academy of Sciences. 2019, 116, 43,  21493-21500.

11. A concise, modular antibody-oligonucleotide conjugation strategy based on disuccinimidyl ester activation chemistry

Gang Li, Raymond E. Moellering*, ChemBioChem, 2019, 20, 12, 1599-1605.

10. Chemical probes for spatially resolved measurement of active enzymes in single cells 

Gang Li, Raymond E. Moellering*, Methods Enzymol. 2019, 628, 243-262.

9. Proteomics reveals NNMT as a master metabolic regulator of cancer associated fibroblasts

Mark A. Eckert#, Fabian Coscia#, Agnieszka Chryplewicz, Jae W. Chang, Kyle M. Hernandez, Shawn Pan, Samantha M. Tienda, Dominik A. Nahotko, Gang Li, Ivana Blaženović, Ricardo R. Lastra, Marion Curtis, S. Diane Yamada, Ruth Perets, Stephanie M. McGregor, Jorge Andrade, Oliver Fiehn, Raymond E. Moellering, Matthias Mann, Ernst Lengyel*, Nature, 2019, 569, 723-728

8. An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells

Gang Li, Jeffrey E. Montgomery, Mark A. Eckert, Jae W. Chang, Sam M. Tienda, Ernest Lengyel, Raymond E. Moellering*, Nature Communications. 2017, 8, 1775-1787.
7. Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

Shreya Mitra, Jeffrey E. Montgomery, Matthew J. Kolar, Gang Li, Kang J. Jeong, Bo Peng, Gregory L. Verdine, Gordon B. Mills, Raymond E. Moellering*,  Nature Communications. 2017, 8, 660-670.

Yun Zhang, Yibin Xue, Gang Li, Haosen Yuan, Tuoping Luo*, Chemical Science. 2016, 7, 5530-5536.

5. Design, preparation, and selection of DNA-encoded dynamic libraries

Gang Li#, Wenlu Zheng#, Zitian Chen#, Yu Zhou, Yu Liu, Junrui Yang, Yanyi Huang, Xiaoyu Li*, Chemical Science. 2015, 6, 7097-7104. 
4. Novel encoding methods for DNA-templated chemical libraries

Gang Li, Wenlu Zheng, Ying Liu, Xiaoyu Li*, Current Opinion in Chemical Biology. 2015, 26, 25-33. 
3. Affinity purification in target identification: the specificity challenge

Wenlu Zheng, Gang Li, Xiaoyu Li*, Archives of Pharmacal Research. 2015, 38, 1661-1685. 

2. Multivalent photoaffinity probe for labeling small molecule binding proteins

Gang Li, Yu Liu, Xuerong Yu, Xiaoyu Li*, Bioconjugate Chemistry. 2014, 25, 6, 1172-1180.

1. Photoaffinity labeling of small-molecule-binding proteins by DNA-templated chemistry

Gang Li, Ying Liu, Yu Liu, Li Chen, Siyu Wu, Yang Liu, Xiaoyu Li*, Angewandte Chemie International Edition. 2013, 52, 36, 9544-9549.